This article is concerned with the Three Seas University Network as a vehicle for the macro-regional development of the Three Seas Initiative area. Based on the existing body of research, the author identifies potential new administrative and legal solutions for advancing cooperation between the higher education and research sectors and local governments. To achieve the research aim, he explores the legal possibilities of enabling the macro-regional development of the Three Seas Initiative area. Following a legal analysis, the author concluded that a networking scheme in the form of the Three Seas University Network would be an effective legal vehicle for fostering the macro-regional development of the region concerned. The Network would intensify international cooperation not only in the fields of education or research, but also, and most importantly, in the sphere of regional development.