This study discusses the outpatient activities of the Congregation of the Sisters of St Elisabeth from 1842 until the outbreak of the First World War. The general outline of this activity was already included in the first Statute of 1842, written in 1844. According to the Statute of 1859, in addition to the three ordinary religious vows, the Sisters took an additional fourth one, defining the specificity of the Congregation and obliging them to care for the sick in private homes and hospitals. The author characterizes the outpatient care of the sick and abandoned, both by the Tertiary of St Francis and the Founder of the Congregation of the Sisters of Elisabeth, M. Klara Wolff, as well as by her spiritual daughters - the Sisters of St Elisabeth, commonly called Elisabethan Sisters, on the example of several institutions. Based on source materials, it discusses in particular the activities during the epidemics and wars raging in the second half of the 19th century. In the final part, it presents the issue of professional formation of sisters in the field of nursing work. Due to the scarcity of sources, the image of the sisters' work was necessarily presented fragmentarily. For this reason, incomplete statistical data are also provided.