The article raises the question of the mutual relation between theology and prayer. Theology is a knowledge about God – the Holiest and as such it should carry out research in a holy manner, which may contribute to the holiness of the person who is connected with theology as a teacher or a student. The question of the relation between theology and prayer belongs to the most fundamental issues concerning the method of theology to which we should constantly refer as to a great source of guidelines for today. Let us focus then on certain statements which appeared in the past centuries and which discussed the relation between theology and prayer trying to find the adequate approach to the spiritual and scientific situation in the field of theology in those times. After this introduction we present a view that the relation may be described as the use of prayer in service of theology. Theology, on the other hand, in its full and traditional sense is total and completed only then, when it constitutes the foundation of piety and leads to prayer. Theology through prayer can permeate the inner life opening itself to the state when we belong to God whom we keep in our heart.